Exaggerated Natural Measles Following Two Rounds of Live Attenuated Vaccine
Posted by vaccinesme on Saturday, January, 31 2009 and filed under Articles
Key topics: Measles

St Geme JW Jr, George BL, Bush BM. Exaggerated natural measles following attenuated virus immunization. Pediatrics. 1976 Jan;57(1):148-9.

An adolescent girl, devoid of a detectable humoral immunity to measles virus despite two inoculations of live, attenuated vaccine, developed an exaggerated atypical rubeola illness following exposure to wild virus. This observation suggests that attenuated virus may be capable of immunologically sensitizing some individuals as has been described with killed virus vaccine.

The vaccine failed to produce antibodies in this girl, and as a result, increased sensitization to the natural (wild) measles - producing exaggerated symptoms.