Friday, 13 December 2024    HomeAbout UsContact Us    









You are here: Home Nutrition


An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults With Marginal Selenium Status
Posted by vaccinesme, in Nutrition
Authored by PubMed
Topics: Selenium

  Mail To Friend    Printer Friendly Bookmark and Share

Broome CS, McArdle F, Kyle JA, Andrews F, Lowe NM, Hart CA, Arthur JR, Jackson MJ. An increase in Selenium intake improves immune function and poliovirus handling in adults with marginal Selenium status. Am J Clin Nutr. 2004 Jul;80(1):154-62.
BACKGROUND: Dietary Selenium intakes in many countries, including the United Kingdom, are lower than international recommendations. No functional consequences of these lower intakes have been recognized, although experimental studies suggest that they might contribute to reduced immune function, increased cancer incidence, and increased susceptibility to viral disease. OBJECTIVE: The objective was to assess whether administration of small Selenium supplements to otherwise healthy UK subjects leads to functional changes in immune status and the rates of clearance and mutation of a picornavirus: live attenuated polio vaccine. DESIGN: Twenty-two adult UK subjects with relatively low plasma Selenium concentrations (<1.2 micromol/L, approximately 60% of those screened) received 50 or 100 microg Se (as sodium selenite) or placebo daily for 15 wk in a double-blind study. All subjects received an oral live attenuated poliomyelitis vaccine after 6 wk and enriched stable (74)Se intravenously 3 wk later. RESULTS: Selenium supplementation increased plasma Selenium concentrations, the body exchangeable Selenium pool (measured by using (74)Se), and lymphocyte phospholipid and cytosolic glutathione peroxidase activities. Selenium supplements augmented the cellular immune response through an increased production of interferon gamma and other cytokines, an earlier peak T cell proliferation, and an increase in T helper cells. Humoral immune responses were unaffected. Selenium-supplemented subjects also showed more rapid clearance of the poliovirus, and the poliovirus reverse transcriptase-polymerase chain reaction products recovered from the feces of the supplemented subjects contained a lower number of mutations. CONCLUSIONS: The data indicate that these subjects had a functional Selenium deficit with suboptimal immune status and a deficit in viral handling. They also suggest that the additional 100 microg Se/d may be insufficient to support optimal function.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.







Topics
Basics
Vaccines
Nutrition
Articles
News

Latest Articles
WHO: Polio Outbreak in Philippines Caused by Vaccine
Effective or Ineffective: Attribute Framing and the Human Papillomavirus (HPV) Vaccine
CNS Demyelination and Quadrivalent HPV Vaccination
Pertussis Infection in Fully Vaccinated Children in Day-Care Centers, Israel
Chemoprevention Trial of Human Hepatitis With Selenium Supplementation in China
Protective Role of Selenium Against Hepatitis B Virus and Primary Liver Cancer in Qidong
An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults With Marginal Selenium Status
Nutritional and Food Protection Against Epidemic Emerging Neuropathy. Epidemiological Findings in the Unique Disease-Free Urban Area of Cuba
Diphtheria-Tetanus-Pertussis Vaccine Administered Simultaneously With Measles Vaccine Is Associated With Increased Morbidity and Poor Growth in Girls
Children Vaccinated With MMR and Higher Risk of Multiple Sclerosis

Pages
No pages found.

Most Popular
Antibody Response To Vaccine Does Not Equal Immunity or Protection
Protective Effect of Childhood Measles Against Degenerative Diseases in Later Life
What Is Vaccine Failure?
Measles Outbreak in Previously Immunized Children, Florida, US
Discontinuation of BCG Vaccine in Japan Leads To Significant Drop in Type 2 Diabetes
The Myth Of Vaccines Causing 20th Century Mortality Decline: Excellent Paper by Mckinlay and Mckinlay
Explosive School-Based Measles Outbreak in Vaccinated Students - Finland
Explaining the Reemergence of Pertussis in Vaccinated Populations
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
Court Rules MMR Vaccine Caused Ben Zeller's Brain Damage: July 2008

Archives (View more)
2019 • November
2011 • December
2011 • October
2010 • February
2009 • June
2009 • May
2009 • April
2009 • March
2009 • February
2009 • January


Copyright © 2024 . All rights reserved. RSSTagsPrivacyLegal and Terms of UseSitemap