Saturday, 25 May 2019    HomeAbout UsContact Us    









You are here: Home Articles


Mild Measles and Secondary Vaccine Failure In A Highly Vaccinated Population
Posted by vaccinesme, in Articles
Topics: Measles Outbreak Vaccine Failure Secondary Vaccine Failure

  Mail To Friend    Printer Friendly Bookmark and Share

Read this study very carefully. Of 122 patients with seroconfirmed measles, 10 of the patients (all previously vaccinated) did not show any detectable IgM antibodies specifically against measles. This group had a significantly milder illness than those who did show IgM antibodies in the blood, whether they were vaccinated or unvaccinated!

Edmonson MB, Addiss DG, McPherson JT, Berg JL, Circo SR, Davis JP. Department of Pediatrics, University of Wisconsin, Madison 53792. Mild measles and secondary vaccine failure during a sustained outbreak in a highly vaccinated population. JAMA. 1990 May 9;263(18):2467-71.

A prolonged school-based outbreak of measles provided an opportunity to study "vaccine-modified" mild measles and secondary vaccine failure. Thirty-six (97%) of 37 unvaccinated patients had rash illnesses that met the Centers for disease Control clinical case definition of measles, but 29 (15%) of 198 vaccinated patients did not, primarily because of low-grade or absent fever. Of 122 patients with seroconfirmed measles, 10 patients (all previously vaccinated) had no detectable measles-specific IgM and significantly milder illness than either vaccinated or unvaccinated patients with IgM-positive serum. Of 108 vaccinated patients with seroconfirmed measles, 17 patients (16%) had IgM-negative serology or rash illnesses that failed to meet the clinical case definition; their mean age (13 years), age at the time of vaccination, and time since vaccination did not differ from those of other vaccinated patients. The occurrence of secondary vaccine failure and vaccine-modified measles does not appear to be a major impediment to measles control in the United States but may lead to underreporting of measles cases and result in overestimation of vaccine efficacy in highly vaccinated populations.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.







Topics
Basics
Vaccines
Nutrition
Articles
News

Latest Articles
Effective or Ineffective: Attribute Framing and the Human Papillomavirus (HPV) Vaccine
CNS Demyelination and Quadrivalent HPV Vaccination
Pertussis Infection in Fully Vaccinated Children in Day-Care Centers, Israel
Chemoprevention Trial of Human Hepatitis With Selenium Supplementation in China
Protective Role of Selenium Against Hepatitis B Virus and Primary Liver Cancer in Qidong
An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults With Marginal Selenium Status
Nutritional and Food Protection Against Epidemic Emerging Neuropathy. Epidemiological Findings in the Unique Disease-Free Urban Area of Cuba
Diphtheria-Tetanus-Pertussis Vaccine Administered Simultaneously With Measles Vaccine Is Associated With Increased Morbidity and Poor Growth in Girls
Children Vaccinated With MMR and Higher Risk of Multiple Sclerosis
A Possible Central Mechanism in Autism Spectrum Disorders

Pages
No pages found.

Most Popular
What Is Vaccine Failure?
Antibody Response To Vaccine Does Not Equal Immunity or Protection
Protective Effect of Childhood Measles Against Degenerative Diseases in Later Life
Measles Outbreak in Previously Immunized Children, Florida, US
Discontinuation of BCG Vaccine in Japan Leads To Significant Drop in Type 2 Diabetes
The Myth Of Vaccines Causing 20th Century Mortality Decline: Excellent Paper by Mckinlay and Mckinlay
Explaining the Reemergence of Pertussis in Vaccinated Populations
Explosive School-Based Measles Outbreak in Vaccinated Students - Finland
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
Graphical Evidence: Vaccination Did Not Save Populations - Data From Australia

Archives (View more)
2011 • December
2011 • October
2010 • February
2009 • June
2009 • May
2009 • April
2009 • March
2009 • February
2009 • January


Popular Topics
mortality declinemeaslesmortality ratesmeasles outbreaksVitamin AVitamin Cmeasles deathsmeasles outbreakvaccine failuresecondary vaccine failuremumpsMMRmumps outbreakrubini strainantibodiesantibodymumps vaccineaseptic meningitisenterovirusechovirusurabe strainrubellapregnancyautismparkinsons diseasemeasles vaccineadverse reactionsGuillain-Barre Syndromebrain injurydeathGeorge Fishervaccine deathvaccine compensationpoliovaccine damagereverse transcriptaseretroviruseschicken poxvaricellapertussiswhooping coughDTPdiptheriatetanusdiabetesBCGHIBHemophilus BasthmaallergiesmercurythimerosalgardasilHPVASDBailey BanksHerd Immunitypneumoniaprevnarpneumococcalotitispediacelpsoriasisflu vaccineHepatitis BHepatitis APseudolymphomaaluminium hydroxideallergyatopyCRSmeningitisinfectionsvaccination policyvaccination scienceOPVoral polio vaccineseroconversionvaccine marketingcervical cancerinfluenzaDPTchickenpoxvaccinationimmunizationnatural immunityvaccine efficacyreinfectionmultiple sclerosisprimary vaccine failureGuillain-BarreSIDSsudden deatharthritisadjuvantsaluminiumchronic fatigueexcitotoxinsimmunoexcitotoxinsSelenium
Copyright © 2019 . All rights reserved. RSSTagsPrivacyLegal and Terms of UseSitemap