Sunday, 28 May 2023    HomeAbout UsContact Us    

You are here: Home Articles

Cutaneous Pseudolymphoma Tied to Vaccinations Containing Aluminum Hydroxide
Posted by vaccinesme, in Articles
Topics: Hepatitis B Hepatitis A Pseudolymphoma Aluminium Hydroxide

  Mail To Friend    Printer Friendly Bookmark and Share

NEW YORK (Reuters Health) Apr 25 - vaccinations containing aluminum hydroxide may induce cutaneous lymphoid hyperplasia (CLH), also called cutaneous Pseudolymphoma, according to a report in the April Journal of the American Academy of Dermatology.

"Long lasting cutaneous lesions occurring at the site of vaccination containing aluminum should lead to biopsy and the search for aluminum in the lymphocytic reaction," Dr. Herve Bachelez from Hopital Saint-Louis, Paris, France told Reuters health.

Dr. Bachelez and colleagues investigated 9 patients presenting with late-onset, persistent CLH at the site of Hepatitis B (8 patients) or Hepatitis A (1 patient) vaccination. The vaccines were all aluminum hydroxide- adsorbed and the lesions appeared a median 3 months after a recall injection of the vaccine.

Histologic evaluation of skin biopsies showed a pandermal dense lymphocytic infiltrate without evidence of cytonuclear atypia, consistent with the diagnosis of CLH.

Muscle biopsies years after the appearance of the skin lesions in 2 patients revealed focal lymphocytic microvasculitis in the muscle tissue in one case and lymphoid hyperplasia in perimuscular fat tissue in the second case.

Electron microscopy and immunohistochemical studies identified aluminum hydroxide within the skin infiltrates in all cases, the researchers note. Four patients had their lesions excised surgically, and two patients were treated successfully with intralesional steroid injection.

These findings, the researchers conclude, warrant "further prospective studies to evaluate the incidence and the clinical course of CLH in the population receiving aluminum hydroxide-containing vaccinations."

Eve Maubec MD et. al. Report: Vaccination-induced cutaneous pseudolymphoma. J Am Acad Dermatol April 2005 . Volume 52 . Number 4

Background: Although mild early cutaneous transient reactions to vaccinations are common, late-onset chronic lesions have been scarcely reported. We report herein a series of 9 patients presenting with cutaneous and subcutaneous Pseudolymphoma.

Observations: Nine patients presenting with late-onset, chronic skin lesions occurring at the site of antihepatitis B (8 cases) and antihepatitis A (one case) vaccination were reported. Histopathologic and immunohistochemic studies, and molecular analysis of clonality of skin biopsy specimens, were performed. Furthermore, the presence of vaccine products was investigated in skin lesions by using histochemical, microanalytic, and electronic microscopy techniques.

Results: Histopathologic studies showed dermal and hypodermal lymphocytic follicular infiltrates with germinal center formation. The center of follicles was mostly composed of B cells without atypia, whereas CD4+ T cells were predominant at the periphery. Molecular analysis of clonality revealed a polyclonal pattern of B-cell and T-cell subsets. Aluminium deposits were evidenced in all cases by using histochemical staining in all cases, and by microanalysis and ultrastructural studies in one case. Associated manifestations were vitiligo (one case) and chronic fatigue with myalgia (two cases).

Conclusion: Cutaneous lymphoid hyperplasia is a potential adverse effect of vaccinations including aluminium hydroxide as an adjuvant. Further prospective studies are warranted to evaluate the incidence of this complication in the immunized population.

Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.


Related Articles:
Add a Comment
You must be registered and logged in to comment.


Latest Articles
WHO: Polio Outbreak in Philippines Caused by Vaccine
Effective or Ineffective: Attribute Framing and the Human Papillomavirus (HPV) Vaccine
CNS Demyelination and Quadrivalent HPV Vaccination
Pertussis Infection in Fully Vaccinated Children in Day-Care Centers, Israel
Chemoprevention Trial of Human Hepatitis With Selenium Supplementation in China
Protective Role of Selenium Against Hepatitis B Virus and Primary Liver Cancer in Qidong
An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults With Marginal Selenium Status
Nutritional and Food Protection Against Epidemic Emerging Neuropathy. Epidemiological Findings in the Unique Disease-Free Urban Area of Cuba
Diphtheria-Tetanus-Pertussis Vaccine Administered Simultaneously With Measles Vaccine Is Associated With Increased Morbidity and Poor Growth in Girls
Children Vaccinated With MMR and Higher Risk of Multiple Sclerosis

No pages found.

Most Popular
Antibody Response To Vaccine Does Not Equal Immunity or Protection
Protective Effect of Childhood Measles Against Degenerative Diseases in Later Life
What Is Vaccine Failure?
Measles Outbreak in Previously Immunized Children, Florida, US
Discontinuation of BCG Vaccine in Japan Leads To Significant Drop in Type 2 Diabetes
The Myth Of Vaccines Causing 20th Century Mortality Decline: Excellent Paper by Mckinlay and Mckinlay
Explosive School-Based Measles Outbreak in Vaccinated Students - Finland
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
Explaining the Reemergence of Pertussis in Vaccinated Populations
Court Rules MMR Vaccine Caused Ben Zeller's Brain Damage: July 2008

Archives (View more)
2019 • November
2011 • December
2011 • October
2010 • February
2009 • June
2009 • May
2009 • April
2009 • March
2009 • February
2009 • January

Copyright © 2023 . All rights reserved. RSSTagsPrivacyLegal and Terms of UseSitemap