Saturday, 04 September 2010    HomeContact Us     




Mumps Outbreak In A Highly Vaccinated School Population. Evidence For Large-Scale Vaccination Failure
Filed under: Articles
Wednesday, January 28 2009 - by vaccinesme
Key topics: Vaccine Failure Mumps Outbreak

Mail to a FriendPrinter friendly

Cheek JE, Baron R, Atlas H, Wilson DL, Crider RD Jr. Division of Field Epidemiology, Centers for Disease Control and Prevention, Atlanta, GA, USA. Mumps Outbreak In A Highly Vaccinated School Population. Evidence For Large-Scale vaccination Failure. Arch Pediatr Adolesc Med. 1995 Jul;149(7):774-8.

OBJECTIVES: To describe an outbreak and to identify risk factors for mumps occurring in a highly vaccinated high school population. (Note: Highly vaccinated means a population in which more than 95% have been vaccinated.) DESIGN AND PARTICIPANTS: Survey and cohort study of 307 (97%) of 318 students. OUTCOME MEASURES: mumps was defined as an illness with 2 or more days of parotid swelling. Serologic confirmation of infection was obtained in eight cases, seven of which were evaluated for presence of IgM antibody using immunofluorescent antibodies. Vaccination records were verified for 297 (97%) students. RESULTS: Between October 3 and November 23, 1990, clinical mumps developed in 54 students (attack rate, 18%), 53 of whom had been vaccinated. Most cases (40 [77%] of 52) occurred 12 to 20 days after a school-wide pep rally. Immunofluorescent antibody testing of all seven specimens demonstrated IgM antibody to mumps. Risk factors for clinical mumps identified in multivariate analyses included female gender (odds ratio, 3.0; 95% confidence interval, 1.6 to 5.7) and source of vaccination other than the local public health clinic (students vaccinated by private providers [odds ratio, 3.0; 95% confidence interval, 1.3 to 5.2] or in other districts [odds ratio, 2.4; 95% confidence interval, 1.1 to 5.3]). CONCLUSIONS: The overall attack rate is the highest reported to date (and to our knowledge) for a population demonstrating virtually complete mumps vaccine coverage. Even verified documentation of vaccination may not be an accurate indicator of an individual's protection against mumps. Vaccination failure may play an important role in contemporary mumps outbreaks. We found no evidence to indicate that waning immunity (secondary vaccine failure) contributed significantly to this outbreak. A second dose of mumps vaccine, as recommended using measles-mumps-rubella vaccine, could potentially prevent similar outbreaks in secondary school populations in the future.



Link to this article:   Show: HTML LinkFull LinkShort Link
Related Articles:



Search This Site
Latest Articles
High Secondary Vaccine Failure Amongst Teenagers Vaccinated For Measles At Young Age
Selected UK MPs Launch Workers' Vaccine Damage Early Day Motion
Childhood Chickenpox Associated With Decreased Risk of Multiple Sclerosis
Protective Effect of Childhood Measles Against Allergies and Atopies
Susceptibility To Asymptomatic Reinfection Amongst Fully Vaccinated Individuals
What Is Vaccine Failure?
Vaccination Is Not Equated Automatically with Development of Immunity
Whooping Cough (Pertussis) In The Fully Vaccinated
Mumps Vaccine Failure in Navarre, Spain
The Rubella Vaccine Scam - A View From Sri Lanka
Most Popular
The Role of The Measles Vaccine in Preventing Measles Deaths in the 20th Century
The Myth Of Vaccines Causing 20th Century Mortality Decline: Excellent Paper by Mckinlay and Mckinlay
Families Win Lawsuit Over MMR Vaccine - Japan
Selected UK MPs Launch Workers' Vaccine Damage Early Day Motion
What Is Vaccine Failure?
Widespread Transmission of Paralytic Polio Amongst Fully Vaccinated Children in Oman
Two Babies Die Days After the MMR Jab
An Explosive Point-Source Measles Outbreak In A Highly Vaccinated Population
Whooping Cough (Pertussis) In The Fully Vaccinated
Baby Dies After Being Given Hib Vaccine

Tags
adverse reactions allergies allergy aluminium hydroxide antibodies antibody asd aseptic meningitis asthma atopy autism bailey banks bcg brain injury cervical cancer chicken pox chickenpox crs death diabetes diptheria dpt dtp echovirus enterovirus flu vaccine gardasil george fisher guillain-barre syndrome hemophilus b hepatitis a hepatitis b herd immunity hib hpv immunization infections influenza measles measles deaths measles outbreak measles outbreaks measles vaccine meningitis mercury mmr mortality decline mortality rates multiple sclerosis mumps mumps outbreak mumps vaccine natural immunity opv oral polio vaccine otitis parkinsons disease pediacel pertussis pneumococcal pneumonia polio pregnancy prevnar primary vaccine failure pseudolymphoma psoriasis reinfection retroviruses reverse transcriptase rubella rubini strain secondary vaccine failure seroconversion tetanus thimerosal urabe strain vaccination vaccination policy vaccination science vaccine compensation vaccine damage vaccine death vaccine efficacy vaccine failure vaccine marketing varicella vitamin a vitamin c whooping cough

Archives
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
September 2009
August 2009
July 2009
June 2009
May 2009
April 2009
March 2009
February 2009
January 2009


Vaccines.Me content is purely for educational purposes and is not to be considered as specific medical advice.

© Vaccines.Me All rights reserved.