D Germann, A Ströhle, K Eggenberger, C A Steiner, L Matter Institute of Medical Microbiology, University of Bern, Switzerland.
An Outbreak Of mumps In A Population Partially Vaccinated With The Rubini Strain.
Scand J Infect Dis. 1996 ;28 (3):235-8
Since 1991, 6 years after the recommendation of universal childhood triple
vaccination against
measles,
mumps and
rubella (M + M + R), Switzerland has been confronted with an increasing number of
mumps cases affecting both vaccinated and unvaccinated children. The M + M + R vaccine mainly used in the Swiss population after 1986 contains the highly attenuated
rubini strain of
mumps virus. We analysed an outbreak of 102 suspected
mumps cases by virus isolation, determination of IgM
antibodies to
mumps virus in 27 acute phase sera, and verification of
vaccination histories.
Mumps was confirmed by virus isolation in 88 patients, of whom 72 had previously received the Rubini vaccine strain. IgM
antibodies to
mumps virus were detected in 24/27 acute phase serum samples. A group of 92 subjects from the same geographic area without signs of
mumps virus infection served as controls. IgG
antibodies to
mumps virus and
vaccination status were assessed in these children. The
vaccination rate in these controls was 61%, with equal seropositivity for unvaccinated and Rubini-vaccinated subjects. These data support other recent reports which indicate an insufficient protective efficacy of current
mumps vaccines.
