Monday, 20 November 2017    HomeAbout UsContact Us    









You are here: Home Articles


Widespread Transmission of Paralytic Polio Amongst Fully Vaccinated Children in Oman
Posted by vaccinesme, in Articles
Topics: Polio Vaccine Failure

  Mail To Friend    Printer Friendly Bookmark and Share

1991: Sutter R W; Patriarca P A; Brogan S; Malankar P G; Pallansch M A; Kew O M; Bass A G; Cochi S L; Alexander J P; Hall D B. Outbreak of paralytic poliomyelitis in Oman: evidence for widespread transmission among fully vaccinated children. Lancet 1991;338(8769):715-20.

From January, 1988, to March, 1989, a widespread outbreak (118 cases) of poliomyelitis type 1 occurred in Oman. Incidence of paralytic disease was highest in children younger than 2 years (87/100,000) despite an immunisation programme that recently had raised coverage with 3 doses of oral poliovirus vaccine (OPV) among 12-month-old children from 67% to 87%. We did a case-control study (70 case-patients, 692 age-matched controls) to estimate the clinical efficacy of OPV, assessed the immunogenicity of OPV and extent of poliovirus spread by serology, retrospectively evaluated the cold chain and vaccine potency, and sought the origin of the outbreak strain by genomic sequencing. 3 doses of OPV reduced the risk of paralysis by 91%; vaccine failures could not be explained by failures in the cold chain nor on suboptimum vaccine potency. Cases and controls had virtually identical type 1 neutralising antibody profiles, suggesting that poliovirus type 1 circulation was widespread. Genomic sequencing indicated that the outbreak strain had been recently imported from South Asia and was distinguishable from isolates indigenous to the Middle East. Accumulation of enough children to sustain the outbreak seems to have been due to previous success of the immunisation programme in reducing spread of endemic strains, suboptimum efficacy of OPV, and delay in completing the primary immunisation series until 7 months of age. Additionally, the estimated attack rate of infection among children aged 9-23 months exceeded 25% in some regions, suggesting that a substantial proportion of fully vaccinated children had been involved in the chain of transmission.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.







Topics
Basics
Vaccines
Nutrition
Articles
News

Latest Articles
Effective or Ineffective: Attribute Framing and the Human Papillomavirus (HPV) Vaccine
CNS Demyelination and Quadrivalent HPV Vaccination
Pertussis Infection in Fully Vaccinated Children in Day-Care Centers, Israel
Chemoprevention Trial of Human Hepatitis With Selenium Supplementation in China
Protective Role of Selenium Against Hepatitis B Virus and Primary Liver Cancer in Qidong
An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults With Marginal Selenium Status
Nutritional and Food Protection Against Epidemic Emerging Neuropathy. Epidemiological Findings in the Unique Disease-Free Urban Area of Cuba
Diphtheria-Tetanus-Pertussis Vaccine Administered Simultaneously With Measles Vaccine Is Associated With Increased Morbidity and Poor Growth in Girls
Children Vaccinated With MMR and Higher Risk of Multiple Sclerosis
A Possible Central Mechanism in Autism Spectrum Disorders

Pages
No pages found.

Most Popular
What Is Vaccine Failure?
Measles Outbreak in Previously Immunized Children, Florida, US
Antibody Response To Vaccine Does Not Equal Immunity or Protection
Protective Effect of Childhood Measles Against Degenerative Diseases in Later Life
Discontinuation of BCG Vaccine in Japan Leads To Significant Drop in Type 2 Diabetes
Explaining the Reemergence of Pertussis in Vaccinated Populations
Explosive School-Based Measles Outbreak in Vaccinated Students - Finland
The Myth Of Vaccines Causing 20th Century Mortality Decline: Excellent Paper by Mckinlay and Mckinlay
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
The Role of The Measles Vaccine in Preventing Measles Deaths in the 20th Century

Archives (View more)
2011 • December
2011 • October
2010 • February
2009 • June
2009 • May
2009 • April
2009 • March
2009 • February
2009 • January


Popular Topics
mortality declinemeaslesmortality ratesmeasles outbreaksVitamin AVitamin Cmeasles deathsmeasles outbreakvaccine failuresecondary vaccine failuremumpsMMRmumps outbreakrubini strainantibodiesantibodymumps vaccineaseptic meningitisenterovirusechovirusurabe strainrubellapregnancyautismparkinsons diseasemeasles vaccineadverse reactionsGuillain-Barre Syndromebrain injurydeathGeorge Fishervaccine deathvaccine compensationpoliovaccine damagereverse transcriptaseretroviruseschicken poxvaricellapertussiswhooping coughDTPdiptheriatetanusdiabetesBCGHIBHemophilus BasthmaallergiesmercurythimerosalgardasilHPVASDBailey BanksHerd Immunitypneumoniaprevnarpneumococcalotitispediacelpsoriasisflu vaccineHepatitis BHepatitis APseudolymphomaaluminium hydroxideallergyatopyCRSmeningitisinfectionsvaccination policyvaccination scienceOPVoral polio vaccineseroconversionvaccine marketingcervical cancerinfluenzaDPTchickenpoxvaccinationimmunizationnatural immunityvaccine efficacyreinfectionmultiple sclerosisprimary vaccine failureGuillain-BarreSIDSsudden deatharthritisadjuvantsaluminiumchronic fatigueexcitotoxinsimmunoexcitotoxinsSelenium
Copyright © 2017 . All rights reserved. RSSTagsPrivacyLegal and Terms of UseSitemap