Wednesday, 24 May 2017    HomeAbout UsContact Us    









You are here: Home Articles


Mumps Vaccine Failure in Navarre, Spain
Posted by vaccinesme, in Articles
Topics: Vaccine Failure Mumps Vaccine Efficacy

  Mail To Friend    Printer Friendly Bookmark and Share

Jesús Castillaa (b), Manuel García Cenoza (b), Maite Arriazua (b), Mirian Fernández-Alonso (c), Víctor Martínez-Artola (d), Jaione Etxeberria (a,b), Fátima Irisarri (a,b) and Aurelio Barricarte (a,b). Effectiveness of Jeryl Lynn-containing vaccine in Spanish children. Volume 27, Issue 15, 26 March 2009, Pages 2089-2093

(a) Instituto de Salud Pública de Navarra, Pamplona, Spain
(b) CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
(c) Clínica Universitaria de Navarra, Pamplona, Spain
(d) Hospital Virgen del Camino, Pamplona, Spain

We evaluated the effectiveness of the Jeryl Lynn strain vaccine in a large outbreak of mumps in Navarre, Spain, 2006-2008. Each of the 241 cases of mumps occurring in children over 15 months of age born between 1998 and 2005 was compared with 5 controls individually matched by sex, birth date, district of residence and paediatrician. vaccination history was obtained blindly from clinical records. Conditional logistic regression was used to obtain the matched odds ratios (ORs), and effectiveness was calculated as 1 - OR. Some 70% of cases had received one dose of measles-mumps-rubella vaccine, and 24% had received two doses. Overall vaccine effectiveness was 72% (95% CI, 39-87%). Two doses were more effective (83%; 54-94%) than a single dose (66%; 25-85%). Among vaccinated children, risk was higher in those who had received the first dose after 36 months of age (OR = 3.1; 1.2-8.4) and those who had received the second dose 3 or more years before study enrolment (OR = 10.2; 1.5-70.7). Early waning of immunity in children after the second dose may contribute to reduced vaccine effectiveness for mumps prevention.

The vast majority of cases were in the vaccinated who received one or two doses of MMR. This is said to occur because a vaccine's "effectiveness" is never 100% and thus a percentage of vaccinated will still get the disease. It appears to be a good way to explain the failure of the vaccine and we will explore this issue in more detail in other articles, looking at "vaccine efficacy", the underlying assumptions involved, and the formulas used to calculate such efficacy.


Link to this article:   Show: HTML LinkFull LinkShort Link
Share or Bookmark this page: You will need to have an account with the selected service in order to post links or bookmark this page.

                 
  
Subscribe via RSS or email:
Follow us through RSS or email. Click the RSS icon to subscribe to our feed.

     
  

Related Articles:
Add a Comment
You must be registered and logged in to comment.







Topics
Basics
Vaccines
Nutrition
Articles
News

Latest Articles
Effective or Ineffective: Attribute Framing and the Human Papillomavirus (HPV) Vaccine
CNS Demyelination and Quadrivalent HPV Vaccination
Pertussis Infection in Fully Vaccinated Children in Day-Care Centers, Israel
Chemoprevention Trial of Human Hepatitis With Selenium Supplementation in China
Protective Role of Selenium Against Hepatitis B Virus and Primary Liver Cancer in Qidong
An Increase in Selenium Intake Improves Immune Function and Poliovirus Handling in Adults With Marginal Selenium Status
Nutritional and Food Protection Against Epidemic Emerging Neuropathy. Epidemiological Findings in the Unique Disease-Free Urban Area of Cuba
Diphtheria-Tetanus-Pertussis Vaccine Administered Simultaneously With Measles Vaccine Is Associated With Increased Morbidity and Poor Growth in Girls
Children Vaccinated With MMR and Higher Risk of Multiple Sclerosis
A Possible Central Mechanism in Autism Spectrum Disorders

Pages
No pages found.

Most Popular
What Is Vaccine Failure?
Measles Outbreak in Previously Immunized Children, Florida, US
Antibody Response To Vaccine Does Not Equal Immunity or Protection
Explaining the Reemergence of Pertussis in Vaccinated Populations
Explosive School-Based Measles Outbreak in Vaccinated Students - Finland
Discontinuation of BCG Vaccine in Japan Leads To Significant Drop in Type 2 Diabetes
The Myth Of Vaccines Causing 20th Century Mortality Decline: Excellent Paper by Mckinlay and Mckinlay
Protective Effect of Childhood Measles Against Degenerative Diseases in Later Life
BCG (Tuberculosis) Vaccine Induced Inflammation Linked to Type 2 Diabetes Epidemic
The Role of The Measles Vaccine in Preventing Measles Deaths in the 20th Century

Archives (View more)
2011 • December
2011 • October
2010 • February
2009 • June
2009 • May
2009 • April
2009 • March
2009 • February
2009 • January


Popular Topics
mortality declinemeaslesmortality ratesmeasles outbreaksVitamin AVitamin Cmeasles deathsmeasles outbreakvaccine failuresecondary vaccine failuremumpsMMRmumps outbreakrubini strainantibodiesantibodymumps vaccineaseptic meningitisenterovirusechovirusurabe strainrubellapregnancyautismparkinsons diseasemeasles vaccineadverse reactionsGuillain-Barre Syndromebrain injurydeathGeorge Fishervaccine deathvaccine compensationpoliovaccine damagereverse transcriptaseretroviruseschicken poxvaricellapertussiswhooping coughDTPdiptheriatetanusdiabetesBCGHIBHemophilus BasthmaallergiesmercurythimerosalgardasilHPVASDBailey BanksHerd Immunitypneumoniaprevnarpneumococcalotitispediacelpsoriasisflu vaccineHepatitis BHepatitis APseudolymphomaaluminium hydroxideallergyatopyCRSmeningitisinfectionsvaccination policyvaccination scienceOPVoral polio vaccineseroconversionvaccine marketingcervical cancerinfluenzaDPTchickenpoxvaccinationimmunizationnatural immunityvaccine efficacyreinfectionmultiple sclerosisprimary vaccine failureGuillain-BarreSIDSsudden deatharthritisadjuvantsaluminiumchronic fatigueexcitotoxinsimmunoexcitotoxinsSelenium
Copyright © 2017 . All rights reserved. RSSTagsPrivacyLegal and Terms of UseSitemap